Abstract
The yeast Sir protein complex has been implicated in transcriptional silencing and suppression of recombination. The Sir complex creates structured chromosomal domains at telomeres, silent mating-type loci and ribosomal DNA to invoke these functional states. Mechanistic insights into the function of Sir proteins implicate a range of activities in yeast, including repair of DNA double-strand breaks, regulation of the mitotic cell cycle, meiosis and ageing. I speculate that the Sir proteins may be capable of enzymatic modification of chromatin and other substrates, which enables them to carry out a broad range of cellular functions.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Cell Cycle / genetics
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Chromatin / genetics
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Chromatin / metabolism
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DNA Repair / genetics
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism*
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Fungal Proteins / genetics
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Fungal Proteins / metabolism*
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Gene Expression Regulation, Fungal
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Gene Silencing*
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Histone Deacetylases*
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Repetitive Sequences, Nucleic Acid / genetics
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Silent Information Regulator Proteins, Saccharomyces cerevisiae*
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Sirtuin 2
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Sirtuins
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Telomere / genetics
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Telomere / metabolism
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Trans-Activators / genetics
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Trans-Activators / metabolism*
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Yeasts / cytology
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Yeasts / enzymology
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Yeasts / genetics*
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Yeasts / metabolism
Substances
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Chromatin
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DNA-Binding Proteins
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Fungal Proteins
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Silent Information Regulator Proteins, Saccharomyces cerevisiae
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Trans-Activators
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SIR2 protein, S cerevisiae
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Sirtuin 2
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Sirtuins
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Histone Deacetylases