Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 77 (4), 277-91

SR-related Proteins and the Processing of Messenger RNA Precursors

Affiliations
  • PMID: 10546891
Review

SR-related Proteins and the Processing of Messenger RNA Precursors

B J Blencowe et al. Biochem Cell Biol.

Abstract

The processing of messenger RNA precursors (pre-mRNA) to mRNA in metazoans requires a large number of proteins that contain domains rich in alternating arginine and serine residues (RS domains). These include members of the SR family of splicing factors and proteins that are structurally and functionally distinct from the SR family, collectively referred to below as SR-related proteins. Both groups of RS domain proteins function in constitutive and regulated pre-mRNA splicing. Recently, several SR-related proteins have been identified that are associated with the transcriptional machinery. Other SR-related proteins are associated with mRNA 3' end formation and have been implicated in export. We review these findings and evidence that proteins containing RS domains may play a fundamental role in coordinating different steps in the synthesis and processing of pre-mRNA.

Similar articles

See all similar articles

Cited by 44 articles

See all "Cited by" articles

Publication types

LinkOut - more resources

Feedback