Safety and immunogenicity of a new Neisseria meningitidis serogroup C-tetanus toxoid conjugate vaccine in healthy adults

Vaccine. 1999 Nov 12;18(7-8):641-6. doi: 10.1016/s0264-410x(99)00276-5.


We evaluated the safety and immunogenicity of a single dose of a new serogroup C O-deacetylated meningococcal polysaccharide-tetanus toxoid conjugate vaccine in 30 healthy adult volunteers. The vaccine was well tolerated with no serious adverse events and minimal local reactions and systemic symptoms. All subjects developed a fourfold or greater increase in serum bactericidal antibody (SBA) to serogroup C meningococcus. SBA geometric mean titre increased from 11 to 3649 (p<0.001). Serogroup C-specific IgG levels increased postvaccination from 0.65 to 17.02 microg/ml (p<0.001). Bactericidal titres pre- and postimmunisation showed significant correlation with serogroup C-specific IgG (r(2)=0.693). Antibody levels fell by 6 months postvaccination, however, meningococcal C IgG avidity increased indicating the successful induction of a T-cell-dependent antibody response.

Conclusion: meningococcal C-tetanus toxoid conjugate vaccine is immunogenic and well tolerated in healthy adults.

Publication types

  • Clinical Trial
  • Clinical Trial, Phase I

MeSH terms

  • Adult
  • Antibodies, Bacterial / blood
  • Antibodies, Bacterial / immunology
  • Antibody Affinity
  • Antibody Specificity
  • Antibody-Dependent Cell Cytotoxicity
  • Bacterial Capsules / immunology
  • Bacterial Vaccines / adverse effects*
  • Bacterial Vaccines / immunology*
  • Female
  • Humans
  • Immunoglobulin G / blood
  • Immunoglobulin G / immunology
  • Immunologic Memory
  • Lymphocyte Activation / immunology
  • Male
  • Middle Aged
  • Neisseria meningitidis / immunology*
  • Polysaccharides, Bacterial / adverse effects*
  • Polysaccharides, Bacterial / immunology*
  • T-Lymphocytes / immunology
  • Tetanus Toxoid / adverse effects*
  • Tetanus Toxoid / immunology*
  • Vaccines, Conjugate / adverse effects
  • Vaccines, Conjugate / immunology


  • Antibodies, Bacterial
  • Bacterial Vaccines
  • Immunoglobulin G
  • Polysaccharides, Bacterial
  • Tetanus Toxoid
  • Vaccines, Conjugate
  • meningococcal group C polysaccharide-tetanus toxoid conjugate