Endometrial CD56+ natural killer cells in women with recurrent miscarriage: a histomorphometric study

Hum Reprod. 1999 Nov;14(11):2727-30. doi: 10.1093/humrep/14.11.2727.


Endometrial natural killer (NK) cells were compared in luteal-phase endometrial samples from women with recurrent miscarriage and from normal subjects. Cryostat sections were labelled using a monoclonal antibody to CD56 using an avidin-biotin complex method and a morphometric study performed. Increased mean numbers of CD56+ cells were documented in the endometrium of women with recurrent early miscarriage only. These findings suggest a possible role for NK cells in the pathogenesis of recurrent early pregnancy loss.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abortion, Habitual / pathology*
  • Adult
  • Antibodies, Monoclonal
  • CD56 Antigen / analysis*
  • Endometrium / immunology
  • Endometrium / pathology*
  • Female
  • Gestational Age
  • Humans
  • Killer Cells, Natural / pathology*
  • Killer Cells, Natural / physiology
  • Lymphocyte Count
  • Pregnancy


  • Antibodies, Monoclonal
  • CD56 Antigen