[Sjögren's syndrome and necrotizing sarcoid-like granulomatosis]

Rev Mal Respir. 1999 Sep;16(4):554-7.
[Article in French]


We report the first description of a Sjögren's syndrome associated with nectrotizing sarcoid-like granulmatosis. A 62-year old woman was admitted for diagnostic exploration of fatigue, weight loss, and fever at 38 degrees C which had progressed for more than 3 months. Chest X-ray showed several pulmonary opacities. There was a history of tuberculosis and thyroiditis at the age of 20 years. Physical examination revealed a sicca syndrome. There was no objective evidence of respiratory disease. Her heart and chest were clear on auscultation. The patient had autoantibodies for SSa and SSb specific antigens. Minor salivary gland biopsy gave a score of 3 in the Chisholm classification. Chest X-ray and CT-scan showed diffuse infiltrative opacities which were dense and peripheral with no retraction. Bronchoalveolar lavage, and bronchial and transbronchial biopsies were non-specific. Surgical lung biopsy showed typical aspects of necrotizing sarcoid-like granulomatosis. After high-dose pulse corticosteroid therapy, the opacities disappeared with no recurrence under oral steroids at three years.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use
  • Diagnosis, Differential
  • Female
  • Granuloma, Respiratory Tract / drug therapy
  • Granuloma, Respiratory Tract / etiology*
  • Granuloma, Respiratory Tract / pathology
  • Humans
  • Middle Aged
  • Necrosis
  • Sarcoidosis, Pulmonary / drug therapy
  • Sarcoidosis, Pulmonary / etiology*
  • Sarcoidosis, Pulmonary / pathology
  • Sjogren's Syndrome / complications*
  • Sjogren's Syndrome / pathology


  • Adrenal Cortex Hormones