Limitations of clinical diagnosis in acute stroke

Lancet. 1999 Oct 30;354(9189):1523. doi: 10.1016/s0140-6736(99)04360-3.


Trials in acute stroke have recruited on the basis of clinical diagnosis. Using MRI we have shown that clinical diagnosis is more limited than previously appreciated, thus trials may have been underpowered or confounded.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Clinical Trials as Topic / statistics & numerical data*
  • Confounding Factors, Epidemiologic
  • Diagnostic Errors / statistics & numerical data*
  • Humans
  • Stroke / diagnosis*
  • Stroke / drug therapy