Pathogenesis, diagnosis, and treatment of acute disseminated encephalomyelitis

Curr Opin Neurol. 1999 Aug;12(4):395-401. doi: 10.1097/00019052-199908000-00005.


Acute disseminated encephalomyelitis is considered a monophasic, inflammatory demyelinating disorder of the central nervous system. A temporal relationship usually exists between the onset of neurologic symptoms and an infection or a vaccination. A viral exanthem facilitates the diagnosis. Some heterogeneity exists with regard to etiology and clinical course of this disease. Immunosuppression is considered the treatment of choice.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Combined Modality Therapy
  • Diagnosis, Differential
  • Encephalomyelitis, Acute Disseminated* / diagnosis
  • Encephalomyelitis, Acute Disseminated* / etiology
  • Encephalomyelitis, Acute Disseminated* / therapy
  • Humans
  • Immunoglobulins, Intravenous / therapeutic use*
  • Plasmapheresis / methods*
  • Viral Vaccines / adverse effects*
  • Virus Diseases / complications*
  • Virus Diseases / prevention & control*


  • Immunoglobulins, Intravenous
  • Viral Vaccines