Antineutrophil cytoplasmic antibodies in systemic lupus erythematosus in childhood

J Rheumatol. 1999 Nov;26(11):2480-1.


Objective: Antineutrophil cytoplasmic antibodies (ANCA) have been found in up to 25% of adults with systemic lupus erythematosus (SLE) and in 69% of affected children. We investigated ANCA and antibodies to myeloperoxidase (MPO) in 50 children with SLE.

Methods: ANCA in serum were measured by indirect immunofluorescence and antibodies to MPO by ELISA.

Results: ANCA were found in 8 (7 perinuclear ANCA, 1 cytoplasmic ANCA) of the 50 sera tested (16%). All the 8 ANCA positive patients were also positive for anti-MPO antibodies. No association with vasculitis or specific organ involvement was observed.

Conclusion: Our results in children are roughly similar to those reported for adults.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antibodies, Antineutrophil Cytoplasmic / analysis*
  • Autoantibodies / analysis
  • Child
  • Child, Preschool
  • Enzyme-Linked Immunosorbent Assay
  • Fluorescent Antibody Technique, Indirect
  • Humans
  • Lupus Erythematosus, Systemic / immunology*
  • Peroxidase / immunology


  • Antibodies, Antineutrophil Cytoplasmic
  • Autoantibodies
  • Peroxidase