Cloning and characterization of B delta, a novel regulatory subunit of protein phosphatase 2A

FEBS Lett. 1999 Nov 5;460(3):462-6. doi: 10.1016/s0014-5793(99)01377-0.


Variable regulatory subunits of protein phosphatase 2A (PP2A) modulate activity, substrate selectivity and subcellular targeting of the enzyme. We have cloned a novel member of the B type regulatory subunit family, B delta, which is most highly related to B alpha. B delta shares with B alpha epitopes previously used to generate subunit-specific antibodies. Like B alpha, but unlike B beta and B gamma which are highly brain-enriched, B delta mRNA and protein expression in tissues is widespread. B delta is a cytosolic subunit of PP2A with a subcellular localization different from B alpha and may therefore target a pool of PP2A holoenzymes to specific substrates.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Brain / enzymology
  • COS Cells
  • Cell Membrane / enzymology
  • Cloning, Molecular
  • Cytosol / enzymology
  • Molecular Sequence Data
  • Organ Specificity / genetics
  • Peptide Fragments / biosynthesis
  • Peptide Fragments / chemistry
  • Peptide Fragments / genetics*
  • Phosphoprotein Phosphatases / biosynthesis
  • Phosphoprotein Phosphatases / chemistry*
  • Phosphoprotein Phosphatases / genetics*
  • Protein Phosphatase 2
  • RNA, Messenger / biosynthesis
  • Rats
  • Signal Transduction


  • Peptide Fragments
  • RNA, Messenger
  • Phosphoprotein Phosphatases
  • Protein Phosphatase 2

Associated data

  • GENBANK/AF180350