CTL priming by CD8(+) and CD8(-) dendritic cells in vivo

Eur J Immunol. 1999 Nov;29(11):3762-7. doi: 10.1002/(SICI)1521-4141(199911)29:11<3762::AID-IMMU3762>3.0.CO;2-F.


Two distinct developmental pathways are driving the formation of myeloid- and lymphoid-related dendritic cells (DC) which differ in anatomical localization and phenotype. In terms of function, it has been hypothesized that only the myeloid-related CD8(-) DC are able to initiate immune responses, whereas the lymphoid-related CD8(+) DC have been suggested to induce tolerance. Here we show that both subsets activate CD8(+) T cells in vitro and induce protective anti-viral CTL responses in vivo. Thus, vaccine strategies using peptide-pulsed DC do not have to take into account DC subsets for priming.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • CD8 Antigens / immunology*
  • Dendritic Cells / immunology*
  • Immunophenotyping
  • Lymph Nodes / immunology
  • Mice
  • Mice, Inbred C57BL
  • Spleen / immunology
  • T-Lymphocytes, Cytotoxic / immunology*


  • CD8 Antigens