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Centrosome Duplication in Mammalian Somatic Cells Requires E2F and Cdk2-cyclin A

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Centrosome Duplication in Mammalian Somatic Cells Requires E2F and Cdk2-cyclin A

P Meraldi et al. Nat Cell Biol.

Abstract

Centrosome duplication is a key requirement for bipolar spindle formation and correct segregation of chromosomes during cell division. In a manner highly reminiscent of DNA replication, the centrosome must be duplicated once, and only once, in each cell cycle. How centrosome duplication is regulated and coordinated with other cell-cycle functions remains poorly understood. Here, we have established a centrosome duplication assay using mammalian somatic cells. We show that centrosome duplication requires the activation of E2F transcription factors and Cdk2-cyclin A activity.

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