Risk of idiopathic venous thromboembolism in users of progestagens alone

Lancet. 1999 Nov 6;354(9190):1610-1. doi: 10.1016/S0140-6736(99)04394-9.


Overall, there was a modest, non-significant, positive association between exposure to progestagens alone and venous thromboembolism (VTE). There was no effect with progestagens alone used for contraception, whereas there was a substantial association with the higher dose progestagens used for other reasons.

Publication types

  • Comment
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Case-Control Studies
  • Cohort Studies
  • Contraceptives, Oral, Synthetic / adverse effects*
  • Female
  • Humans
  • Middle Aged
  • Pregnancy
  • Progestins / adverse effects*
  • Pulmonary Embolism / chemically induced
  • Risk Factors
  • Venous Thrombosis / chemically induced*


  • Contraceptives, Oral, Synthetic
  • Progestins