Treatment of amitriptyline poisoning with ovine antibody to tricyclic antidepressants

Lancet. 1999 Nov 6;354(9190):1614-5. doi: 10.1016/S0140-6736(99)03358-9.

Abstract

We report clinical improvement with the use of an ovine antibody (Fab fragment) to tricyclic antidepressants for the treatment of toxic effects of amitriptyline on the central nervous system and heart in a 48-year-old man.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Adult
  • Amitriptyline / poisoning*
  • Anti-Anxiety Agents / poisoning
  • Antidepressive Agents, Tricyclic / poisoning*
  • Coma / chemically induced*
  • Coma / drug therapy
  • Humans
  • Immunoglobulin Fab Fragments / therapeutic use*
  • Immunoglobulin Fragments / therapeutic use*
  • Infusions, Intravenous
  • Lorazepam / poisoning
  • Male
  • Suicide, Attempted
  • Ventricular Premature Complexes / chemically induced*
  • Ventricular Premature Complexes / drug therapy

Substances

  • Anti-Anxiety Agents
  • Antidepressive Agents, Tricyclic
  • Immunoglobulin Fab Fragments
  • Immunoglobulin Fragments
  • Amitriptyline
  • Lorazepam