Effect of age on the percentage of hemoglobin A1c and the percentage of total glycohemoglobin in non-diabetic persons

J Lab Clin Med. 1999 Nov;134(5):451-3. doi: 10.1016/s0022-2143(99)90165-8.


The purpose of this study was to determine the correlation between age and the percentage of total glycohemoglobin (%tGHb) and that of hemoglobin Alc (%HbA1c) in an adult population without known diabetes. The %tGHb was determined by a semi-automated gravity elution method and by an automated high-performance liquid chromatography (HPLC) method in 210 and 147 subjects without known diabetes, respectively. The %HbA1c, was determined by ion-exchange HPLC in 109 subjects without known diabetes. There was a modest age-related increase in %tGHb and %HbA1c. The mean increase was approximately 0.11% to 0.15% per decade depending on the analytic method used. However, the variance was very large. In conclusion, there is an age-related increase in %tGHb and %HbA1c. However, the increase is only modest and has only a minor effect on a determined reference range in adults.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging / blood*
  • Chromatography, High Pressure Liquid
  • Diabetes Mellitus / blood
  • Glycated Hemoglobin A / metabolism*
  • Humans
  • Middle Aged
  • Reference Values


  • Glycated Hemoglobin A