Extracellular-matrix-binding proteins as targets for the prevention of Staphylococcus aureus infections

Mol Med Today. 1999 Dec;5(12):532-7. doi: 10.1016/s1357-4310(99)01597-x.


Staphylococcal infections cause a number of serious diseases, ranging from acute septicaemia to chronic problems such as osteomyelitis and septic arthritis. Resistance to antibiotics is a growing problem and has re-ignited interest in vaccines and in passive immunization with antibodies. Natural infections and vaccines based on whole bacteria lead to poor antibody responses, but recent research using animal models of several staphylococcal diseases reveals that vaccines based on recombinant staphylococcal extracellular-matrix-binding proteins are much more protective. Passive immunization with antibodies against one of these proteins (collagen-binding protein) also shows promise in a mouse model of sepsis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adhesins, Bacterial / administration & dosage*
  • Adhesins, Bacterial / biosynthesis
  • Adhesins, Bacterial / immunology
  • Animals
  • Antibodies, Bacterial / administration & dosage
  • Disease Models, Animal
  • Immunization, Passive
  • Rats
  • Recombinant Proteins / immunology
  • Staphylococcal Infections / prevention & control*
  • Staphylococcal Vaccines / administration & dosage*
  • Staphylococcal Vaccines / immunology
  • Staphylococcus aureus / genetics*
  • Staphylococcus aureus / metabolism
  • Vaccination*


  • Adhesins, Bacterial
  • Antibodies, Bacterial
  • Recombinant Proteins
  • Staphylococcal Vaccines
  • emb protein, Abiotrophia defectiva