Vitamin D and regulation of gene expression

Curr Opin Clin Nutr Metab Care. 1998 Jul;1(4):347-54. doi: 10.1097/00075197-199807000-00006.


The function of 1,25-dihydroxyvitamin D3, the biologically active form of vitamin D, extends from bone and mineral homeostasis to the control of cell growth and differentiation in a variety of tissues. Most of these actions are mediated by activation of the nuclear vitamin D receptor, which regulates the transcription of vitamin D target genes. Considerable progress has been made in the understanding of vitamin D receptor function (especially regarding its interaction with coactivators), as well as in the identification of novel vitamin D responsive genes related to cell growth, differentiation and cytokine production.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Calcitriol / pharmacology*
  • Cell Differentiation / drug effects
  • Cell Division / drug effects
  • Gene Expression Regulation / drug effects*
  • Humans
  • Vitamin D / pharmacology*


  • Vitamin D
  • Calcitriol