Effect of weight loss on muscle fiber type, fiber size, capillarity, and succinate dehydrogenase activity in humans

J Clin Endocrinol Metab. 1999 Nov;84(11):4185-90. doi: 10.1210/jcem.84.11.6090.


To examine the effects of weight loss on muscle oxidative properties, nine obese subjects (body mass index, 34 +/- 1.5) had muscle biopsies before and after weight loss and weight stabilization. Weight loss ranged from 13-32 kg and represented 20.8 +/- 2.1% of initial weight. After weight loss, there was no change in the proportions of oxidative (type I and type IIa) fibers and also no change in mean fiber cross-sectional area, whereas there was a small, but significant, decrease in the relative interstitial space (P < 0.05). However, weight loss resulted in a 32 +/- 6% (mean +/- SEM) increase in capillary/fiber ratio and a 54% increase in capillary density (P < 0.05). In addition, there was a 41 +/- 13% increase in succinate dehydrogenase (SDH) activity (P < 0.05). This increase in muscle capillarization and SDH activity was seen in all fiber types, even the relatively lower oxidative type IIx fibers. There was a strong correlation between the change in capillary/fiber ratio and the change in SDH activity (r = 0.82; P < 0.02). Thus, weight loss resulted in no change in muscle fiber type or cross-sectional area, but produced increases in capillary/fiber ratio, capillary density, and SDH activity, suggesting an increase in muscle oxidative capacity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Biopsy
  • Capillaries / pathology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Muscle Fibers, Fast-Twitch / enzymology
  • Muscle Fibers, Fast-Twitch / pathology
  • Muscle Fibers, Skeletal / enzymology
  • Muscle Fibers, Skeletal / pathology*
  • Muscle Fibers, Slow-Twitch / enzymology
  • Muscle Fibers, Slow-Twitch / pathology
  • Muscle, Skeletal / blood supply*
  • Muscle, Skeletal / enzymology
  • Muscle, Skeletal / pathology*
  • Obesity / enzymology
  • Obesity / pathology
  • Obesity / therapy*
  • Oxidation-Reduction
  • Succinate Dehydrogenase / metabolism*
  • Weight Loss*


  • Succinate Dehydrogenase