Amyloid-beta binds catalase with high affinity and inhibits hydrogen peroxide breakdown

N G Milton

Amyloid-beta binds catalase with high affinity and inhibits hydrogen peroxide breakdown

Biochem J. 1999 Dec 1;344 Pt 2(Pt 2):293-6.

Author

N G Milton¹

Affiliation

¹ Department of Molecular Pathology, Royal Free and University College Medical School, University College London, Royal Free Campus, Rowland Hill Street, London NW3 2PF, U.K. nmilton@rfhsm.ac.uk

PMID: 10567208
PMCID: PMC1220643

Abstract

Amyloid-beta (Abeta) specifically bound purified catalase with high affinity and inhibited catalase breakdown of H(2)O(2). The Abeta-induced catalase inhibition involved formation of the inactive catalase Compound II and was reversible. Catalase<-->Abeta interactions provide rapid functional assays for the cytotoxic domain of Abeta and suggest a mechanism for some of the observed actions of Abeta plus catalase in vitro.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amyloid beta-Peptides / metabolism*
Amyloid beta-Peptides / toxicity
Catalase / antagonists & inhibitors
Catalase / metabolism*
Hydrogen Peroxide / metabolism*
Peptide Fragments / metabolism
Peptide Fragments / toxicity
Protein Binding

Substances

Amyloid beta-Peptides
Peptide Fragments
Hydrogen Peroxide
Catalase