Amyloid-beta binds catalase with high affinity and inhibits hydrogen peroxide breakdown

Biochem J. 1999 Dec 1;344 Pt 2(Pt 2):293-6.


Amyloid-beta (Abeta) specifically bound purified catalase with high affinity and inhibited catalase breakdown of H(2)O(2). The Abeta-induced catalase inhibition involved formation of the inactive catalase Compound II and was reversible. Catalase<-->Abeta interactions provide rapid functional assays for the cytotoxic domain of Abeta and suggest a mechanism for some of the observed actions of Abeta plus catalase in vitro.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amyloid beta-Peptides / metabolism*
  • Amyloid beta-Peptides / toxicity
  • Catalase / antagonists & inhibitors
  • Catalase / metabolism*
  • Hydrogen Peroxide / metabolism*
  • Peptide Fragments / metabolism
  • Peptide Fragments / toxicity
  • Protein Binding


  • Amyloid beta-Peptides
  • Peptide Fragments
  • Hydrogen Peroxide
  • Catalase