[Dysembryoplastic neuroepithelial tumors. Analysis of 16 cases]

Neurochirurgie. 1999 Sep;45(3):180-9.
[Article in French]


Objectives: We report on 16 cases of dysembryoplastic Neuroepithelial tumor (DNT) treated in the Nancy University Hospital from 1987 to 1997.

Patients and methods: There were 9 males and 7 females. Mean age at onset of symptoms was 9.5 years (range: 3 months to 29 years) and the mean age at surgery was 16 years. Nine patients experienced partial complex seizures, 5 patients generalized seizures, 1 patient partial seizures with secondary generalization and one patient ataxia. The diagnosis of DNT was made under consideration of clinical, radiological and neuropathological features. All patients underwent surgery.

Results: Removal of the tumor was complete for 10 patients, subtotal or partial for 6 patients. Histological examination revealed that 7 cases were specific forms of DNT due to the presence of the specific glioneuronal element. For the 9 remained cases, the diagnosis of DNT could only be made with the consideration of clinical and radiological features. Mean post-surgical follow-up was 3.5 years (range: 1-8 years). Eight patients were seizures-free, 7 had a significative reduction in seizures frequency with minimal anti-convulsivant treatment. The patient with ataxia remained unchanged. For the patients with partial resection of the tumor, follow-up MRI and CT scan showed no significant growth of the remnant and the remaining patients have had no recurrence to date.

Conclusion: The recognition of this surgically curable entity is mandatory. Knowledge of the good prognosis associated with the DNT is essential to avoid deleterious side effects of overtreatment by radiotherapy and/or chemotherapy.

Publication types

  • English Abstract

MeSH terms

  • Adolescent
  • Adult
  • Age of Onset
  • Brain Neoplasms / complications
  • Brain Neoplasms / diagnosis*
  • Brain Neoplasms / surgery
  • Child
  • Child, Preschool
  • Combined Modality Therapy
  • Epilepsy / diagnosis*
  • Epilepsy / etiology
  • Epilepsy / surgery
  • Female
  • Humans
  • Infant
  • Male
  • Neoplasms, Neuroepithelial / complications
  • Neoplasms, Neuroepithelial / diagnosis*
  • Neoplasms, Neuroepithelial / surgery
  • Retrospective Studies
  • Treatment Outcome