Biochemical studies on a novel antioxidant from lemon oil and its biotechnological application in cosmetic dermatology

Drugs Exp Clin Res. 1999;25(5):219-25.


It is generally accepted that lipid peroxides play an important role in the pathogenesis of free radical-induced cellular injury and that antioxidants such as glutathione, ascorbic acid and alpha-tocopherol are vital in cellular defense against endogenous and exogenous oxidants. The purpose of this study was to investigate the effectiveness of a natural compound, derived from lemon oil extract, in controlling free radical-induced lipid peroxidation and tissue damage in the skin. We provide evidence that a compound isolated from lemon oil, which we have called Lem1, is endowed with a strong antioxidant activity and that it is capable of inhibiting free radical-mediated reactions, evaluated by both in vitro and in vivo biochemical systems. The present study aims to give a preclinical perspective on the biochemical properties of Lem1, a natural compound, as well as to provide a better understanding of the endogenous antioxidant potential of skin and the real validity of a natural antioxidant biotechnology in the antiaging management of the skin.

MeSH terms

  • Adolescent
  • Adult
  • Antioxidants / isolation & purification
  • Antioxidants / pharmacology*
  • Biotechnology
  • Chromatography, High Pressure Liquid
  • Citrus
  • Cosmetics
  • Dermatologic Agents / isolation & purification
  • Dermatologic Agents / pharmacology*
  • Drug Evaluation
  • Free Radicals / metabolism
  • Humans
  • In Vitro Techniques
  • Lipid Peroxidation / drug effects
  • Male
  • Middle Aged
  • Plant Oils / chemistry*
  • Skin / drug effects*
  • Skin / metabolism


  • Antioxidants
  • Cosmetics
  • Dermatologic Agents
  • Free Radicals
  • Plant Oils