Etoposide-induced pulmonary toxicity

Lung Cancer. 1999 Nov;26(2):109-12. doi: 10.1016/s0169-5002(99)00081-1.


After treatment with etoposide, two patients with lung cancer developed interstitial infiltrates and respiratory failure. Of the two, one patient responded rapidly to steroid therapy and developed recurrent symptoms on re-challenge with etoposide. Both patients had histopathologic findings consistent with drug-induced pulmonary toxicity. Etoposide-induced lung disease needs to be considered in patients who develop subacute dyspnea and interstitial infiltrates during treatment with this agent.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Antineoplastic Agents, Phytogenic / adverse effects*
  • Diagnosis, Differential
  • Dyspnea / etiology
  • Etoposide / adverse effects*
  • Female
  • Humans
  • Lung Neoplasms / drug therapy*
  • Male
  • Pulmonary Fibrosis / chemically induced*
  • Pulmonary Fibrosis / diagnosis


  • Antineoplastic Agents, Phytogenic
  • Etoposide