Anabolic effects of insulin-like growth factor in combination with insulin-like growth factor binding protein-3 in severely burned adults

J Trauma. 1999 Nov;47(5):904-10; discussion 910-1. doi: 10.1097/00005373-199911000-00015.


Background: The purpose of this study was to determine the anabolic effects of recombinant human insulin-like growth factor-I (rhIGF-1) complexed with its principal binding protein IGF-1 binding protein-3 (IGFBP-3) in severely burned adults.

Methods: Ten burned adults were studied consecutively after receiving saline (pretreatment), then rhIGF-1/IGFBP-3 (treatment) for 5 days. Doses were 1, 2, and 4 mg/kg per day. Glucose, electrolytes, hormones, and leg muscle protein metabolism were determined. Nine other studies were performed on similarly injured adults at comparable times to the treatment studies to control for time effects.

Results: Serum IGF-1 and IGFBP-3 levels increased with all doses, but no incremental increases were found. Leg protein balance improved with rhIGF-1/IGFBP-3, which was associated with an increase in muscle protein fractional synthetic rate. These effects were independent of time. All patients were euglycemic without electrolyte imbalances.

Conclusion: Net protein synthesis in the isolated leg of severely burned adults improved with rhIGF-1/IGFBP-3 without development of glucose abnormalities.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Burns / drug therapy*
  • Burns / physiopathology
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Energy Metabolism / drug effects
  • Energy Metabolism / physiology
  • Female
  • Humans
  • Insulin-Like Growth Factor Binding Protein 3 / administration & dosage*
  • Insulin-Like Growth Factor Binding Protein 3 / blood
  • Insulin-Like Growth Factor I / administration & dosage*
  • Insulin-Like Growth Factor I / metabolism
  • Male
  • Middle Aged
  • Muscle Proteins / metabolism
  • Recombinant Proteins / administration & dosage


  • Insulin-Like Growth Factor Binding Protein 3
  • Muscle Proteins
  • Recombinant Proteins
  • Insulin-Like Growth Factor I