Oligosaccharides in human milk during different phases of lactation

Acta Paediatr Suppl. 1999 Aug;88(430):89-94. doi: 10.1111/j.1651-2227.1999.tb01307.x.


Twenty-one oligosaccharides of human milk were quantified by high-performance anion-exchange chromatography. Milk samples were collected from 18 mothers during the first 3 mo of lactation. The data show that the highest amount of all oligosaccharides is present at day 4 postpartum (20 g l(-1)) and then decreases by about 20% at day 30 of lactation. The protective role played by these substances against different infectious agents, in different organs and systems of the breastfed baby, is emphasized.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Chromatography, High Pressure Liquid
  • Chromatography, Ion Exchange
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Lactation*
  • Longitudinal Studies
  • Milk, Human / chemistry*
  • Oligosaccharides / analysis*
  • Postpartum Period
  • Sensitivity and Specificity
  • Time Factors


  • Oligosaccharides