Functional integration of neural grafts in Parkinson's disease

Nat Neurosci. 1999 Dec;2(12):1047-8. doi: 10.1038/15969.

Abstract

Functional imaging in a Parkinson's patient with a neural transplant shows that the graft is still functional after ten years, and that dopamine from the graft can bind to postsynaptic sites.

Publication types

  • Comment
  • News

MeSH terms

  • Amphetamine / metabolism
  • Amphetamine / pharmacology
  • Binding Sites / drug effects
  • Brain Tissue Transplantation*
  • Controlled Clinical Trials as Topic
  • Dopamine / metabolism*
  • Fetal Tissue Transplantation*
  • Graft Survival*
  • Humans
  • Neurons / metabolism
  • Neurons / transplantation*
  • Parkinson Disease / drug therapy
  • Parkinson Disease / metabolism*
  • Parkinson Disease / pathology
  • Parkinson Disease / surgery*
  • Presynaptic Terminals / drug effects
  • Presynaptic Terminals / metabolism
  • Raclopride / metabolism
  • Receptors, Dopamine D2 / metabolism
  • Tomography, Emission-Computed / methods

Substances

  • Receptors, Dopamine D2
  • Raclopride
  • Amphetamine
  • Dopamine