Mucin-type O-glycans and leukosialin

Biochim Biophys Acta. 1999 Oct 8;1455(2-3):205-17. doi: 10.1016/s0925-4439(99)00067-8.

Abstract

Mucin-type O-glycans on leukocytes acquire functions once they contain core 2 branches, which can be synthesized by core 2 beta1,6-N-acetylglucosaminyltransferase (C2GnT). Recently, understanding the roles of mucin-type O-glycans has been significantly advanced by generating transgenic mice overexpressing C2GnT or knockout mice defective in C2GnT. This review article summarizes previous results implicating the roles of mucin-type O-glycans and the most recent studies to test such a hypothesis. These results, taken together, demonstrate that mucin-type O-glycans either facilitate or attenuate cell adhesion depending on the structures of non-reducing termini.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Antigens, CD / chemistry*
  • Antigens, CD / genetics
  • Biomarkers, Tumor / analysis
  • Carbohydrate Sequence
  • Cell Adhesion*
  • Cell Line
  • DNA, Complementary / chemistry
  • Humans
  • Leukosialin
  • Lewis Blood Group Antigens
  • Lewis X Antigen
  • Molecular Sequence Data
  • Molecular Weight
  • Mucins / metabolism*
  • N-Acetylglucosaminyltransferases / genetics
  • N-Acetylglucosaminyltransferases / metabolism*
  • Oligosaccharides / analysis
  • Sialoglycoproteins / chemistry*
  • Sialoglycoproteins / genetics
  • T-Lymphocytes / chemistry
  • T-Lymphocytes / enzymology
  • T-Lymphocytes / immunology
  • Thymus Gland / chemistry
  • Thymus Gland / cytology
  • Tumor Cells, Cultured
  • Wiskott-Aldrich Syndrome / immunology

Substances

  • Antigens, CD
  • Biomarkers, Tumor
  • DNA, Complementary
  • Leukosialin
  • Lewis Blood Group Antigens
  • Lewis X Antigen
  • Mucins
  • Oligosaccharides
  • Sialoglycoproteins
  • UN1 sialoglycoprotein, human
  • lewis(a)-lewis(x)
  • N-Acetylglucosaminyltransferases
  • beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3
  • beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-acetylglucosaminyl transferase