Wasalexins A and B, new phytoalexins from wasabi: isolation, synthesis, and antifungal activity

Bioorg Med Chem Lett. 1999 Oct 18;9(20):3015-20. doi: 10.1016/s0960-894x(99)00523-5.

Abstract

The chemical structure determination of two phytoalexins from wasabi (Wasabia japonica, syn. Eutrema wasabi), a plant resistant to virulent isolates of the blackleg fungus [Leptosphaeria maculans (Desm.) Ces. et de Not., asexual stage Phoma lingam (Tode ex Fr.) Desm.], as well as their synthesis and antifungal activity towards isolates of P. lingam and P. wasabiae is reported.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents / chemical synthesis
  • Antifungal Agents / isolation & purification*
  • Antifungal Agents / pharmacology
  • Brassicaceae / chemistry*
  • Indoles / chemistry
  • Indoles / isolation & purification*
  • Indoles / pharmacology
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Molecular Structure
  • Sulfides / chemistry
  • Sulfides / isolation & purification*
  • Sulfides / pharmacology

Substances

  • Antifungal Agents
  • Indoles
  • Sulfides
  • wasalexin A