Abnormality in saccadic eye movement in dementia

Eur Psychiatry. 1999 Mar;14(1):52-3. doi: 10.1016/s0924-9338(99)80716-0.


In a small (n = 15) clinically heterogeneous group of patients with dementia of the Alzheimer-type or vascular dementia, abnormally high frequency of saccadic intrusions during fixation was significantly correlated to the Mini-Mental-State-Examination (MMSE) scores. In addition, the latency of saccades and hypometric saccades also correlated significantly to MMSE-scores. The results point to the possible use of saccadic eye movement as a physiological marker of cognitive performance.

MeSH terms

  • Aged
  • Dementia / diagnosis*
  • Female
  • Humans
  • Male
  • Neuropsychological Tests
  • Periodicity
  • Psychiatric Status Rating Scales
  • Saccades / physiology*
  • Severity of Illness Index