The effects of trazodone on sleep disturbances induced by brofaromine

Eur Psychiatry. 1999 Jun;14(3):167-71. doi: 10.1016/s0924-9338(99)80736-6.


The effects of trazodone on subjective and objective sleep parameters were compared to those of placebo in a double-blind design in seven patients who developed insomnia during treatment with the selective and reversible MAO-A inhibitor, brofaromine. Trazodone significantly increased deep sleep and altered the architecture of sleep in these patients. Subjectively, patients reported a better and deeper sleep. No negative interactions between brofaromine and trazodone were observed and side-effects were minimal. A low dose of trazodone may be a safe and effective agent in the treatment of MAO-I induced insomnia.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Electroencephalography
  • Follow-Up Studies
  • Humans
  • Monoamine Oxidase Inhibitors / adverse effects*
  • Piperidines / adverse effects*
  • Serotonin Uptake Inhibitors / therapeutic use*
  • Sleep Initiation and Maintenance Disorders / chemically induced*
  • Sleep Initiation and Maintenance Disorders / drug therapy*
  • Sleep, REM / drug effects*
  • Trazodone / pharmacology*
  • Trazodone / therapeutic use*
  • Wakefulness / drug effects


  • Monoamine Oxidase Inhibitors
  • Piperidines
  • Serotonin Uptake Inhibitors
  • brofaromine
  • Trazodone