[The pharmacological correction of the immune homeostasis disorders in acute dichloroethane poisoning]

Abstract

Experiments on Wistar rats and noninbred mice showed that dipyroxim (10 mg/kg administered 3 times per 24 h) and thymogen (10 mg/kg daily for 3 days) restore the reduced under the effect of acute dichlorethane poisoning in a dose of 0.75 LD50 the organism's anti-infectious unspecific resistance and the main humoral and cell immune reactions. Summing of the effects of the drugs under study was encountered in the case of the T-dependent humoral immune response. The effect of dipyroxim was due to restoration of alpha-naphthyl-AS-acetatesterase of immunocytes and, possibly, other types of esterases of T-cells, macrophages, and monocytes.