Serum p53 Autoantibodies in Patients With Minimal Lesions of Ductal Carcinoma in Situ of the Breast

Br J Cancer. 1999 Oct;81(4):702-4. doi: 10.1038/sj.bjc.6690751.


Five of 43 patients (11.6%) with ductal carcinoma in situ of the breast presented with p53 autoantibodies at diagnosis. Three seropositive patients demonstrated tumour sizes of < or = 5 mm. There was no association of p53 autoantibody status with age, clinical presentation, histological subtype, tumour size, grading, p53 immunohistochemistry or hormone receptor status.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Autoantibodies / blood*
  • Breast Neoplasms / immunology*
  • Breast Neoplasms / pathology
  • Carcinoma in Situ / immunology*
  • Carcinoma, Ductal, Breast / immunology*
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Middle Aged
  • Tumor Suppressor Protein p53 / analysis
  • Tumor Suppressor Protein p53 / immunology*


  • Autoantibodies
  • Tumor Suppressor Protein p53