Peroxisome proliferator-activated receptor-gamma: a versatile metabolic regulator

Ann Med. 1999 Oct;31(5):342-51. doi: 10.3109/07853899908995901.

Abstract

The peroxisome proliferator-activated receptor-gamma (PPARgamma) is a nuclear receptor that controls the expression of a large array of genes involved in adipocyte differentiation, lipid storage and insulin sensitization. PPARgamma is bound and activated by prostaglandin J2 and fatty acid derivatives, which are its natural ligands. In addition, thiazolidinediones and nonsteroidal anti-inflammatory drugs are synthetic ligands and agonists of this receptor. Several studies have recently shown that this nuclear receptor has a role expanding beyond metabolism (diabetes and obesity) with functions in cell cycle control, carcinogenesis, inflammation and atherosclerosis. This review addresses the role of PPARgamma in these processes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adipocytes / metabolism
  • Adipocytes / pathology
  • Animals
  • Cell Cycle
  • Diabetes Mellitus / genetics*
  • Fatty Acids / genetics*
  • Fatty Acids / metabolism
  • Gene Expression
  • Humans
  • Neoplasms / metabolism
  • Nuclear Proteins / metabolism*
  • Obesity / genetics*
  • Receptors, Cytoplasmic and Nuclear / genetics
  • Receptors, Cytoplasmic and Nuclear / metabolism*
  • Sensitivity and Specificity
  • Transcription Factors / genetics
  • Transcription Factors / metabolism*

Substances

  • Fatty Acids
  • Nuclear Proteins
  • Receptors, Cytoplasmic and Nuclear
  • Transcription Factors