Elevation of hypothalamic neuropeptide Y-neurons in adult offspring of diabetic mother rats

Neuroreport. 1999 Oct 19;10(15):3211-6. doi: 10.1097/00001756-199910190-00016.

Abstract

We recently reported on an elevation of neurons expressing the main orexigenic peptide neuropeptide Y (NPY) in the arcuate hypothalamic nucleus (ARC) of neonatally hyperinsulinaemic offspring of gestational diabetic mother rats (GD) at weaning. To investigate possible consequences, the long-term outcome of those animals was examined. At adult age, GD offspring showed hyperphagia (p < 0.001), basal hyperinsulinaemia (p < 0.05) and impaired glucose tolerance (p < 0.05), and were overweight (p < 0.01). This was accompanied by an elevated number of NPY neurons (p < 0.001) and galanin neurons (p < 0.001) in the ARC in adult GD offspring under basal conditions. These findings support our hypothesis on perinatally acquired, persisting malformation and/or malprogramming of peptidergic hypothalamic neurons in the offspring of GD mothers, possibly promoting the development of overweight and diabetogenic disturbances during life.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents / pharmacology
  • Arcuate Nucleus of Hypothalamus / metabolism*
  • Arcuate Nucleus of Hypothalamus / pathology
  • Diabetes Mellitus, Experimental / pathology
  • Diabetes Mellitus, Experimental / physiopathology*
  • Diabetes, Gestational / pathology
  • Diabetes, Gestational / physiopathology*
  • Female
  • Galanin / analysis*
  • Galanin / physiology*
  • Glucose / pharmacology
  • Glucose Tolerance Test
  • Immunohistochemistry
  • Insulin Resistance / physiology*
  • Neurons / metabolism*
  • Neurons / pathology
  • Neurons / physiology
  • Neuropeptide Y / analysis*
  • Neuropeptide Y / physiology
  • Pregnancy
  • Rats
  • Rats, Wistar
  • Streptozocin / pharmacology

Substances

  • Anti-Bacterial Agents
  • Neuropeptide Y
  • Streptozocin
  • Galanin
  • Glucose