Fluorescent molecular probes V: a sensitive caspase-3 substrate for fluorometric assays

J Liu; M Bhalgat; C Zhang; Z Diwu; B Hoyland; D H Klaubert

doi:10.1016/s0960-894x(99)00566-1

Fluorescent molecular probes V: a sensitive caspase-3 substrate for fluorometric assays

Bioorg Med Chem Lett. 1999 Nov 15;9(22):3231-6. doi: 10.1016/s0960-894x(99)00566-1.

Authors

J Liu¹, M Bhalgat, C Zhang, Z Diwu, B Hoyland, D H Klaubert

Affiliation

¹ Molecular Probes, Inc., Eugene, OR 97402, USA.

PMID: 10576694
DOI: 10.1016/s0960-894x(99)00566-1

Abstract

(Z-Asp-Glu-Val-Asp)-Rhodamine 110 [(Z-DEVD)2-Rh 110] was prepared and characterized as a sensitive fluorogenic substrate for the determination of caspase-3 activity.

MeSH terms

Caspase 3
Caspases / metabolism*
Fluorescent Dyes / metabolism*
Sensitivity and Specificity
Substrate Specificity

Substances

Fluorescent Dyes
Caspase 3
Caspases