Synthesis, structural elucidation and pharmacological properties of some 5-acetyl-3,4-dihydro-6-methyl-4-(substituted phenyl)-2(1H) -pyrimidinones

Farmaco. 1999 Jun 30;54(6):359-63. doi: 10.1016/s0014-827x(99)00042-7.

Abstract

In this study, the synthesis of some new 5-acetyl-3,4-dihydro-6-methyl-4-(substituted phenyl)-2(1H)-pyrimidinones has been reported. The compounds were prepared by the Biginelli reaction of acetylacetone with aromatic aldehydes and urea. The structures of the compounds were characterized by UV, IR, 1H NMR, 13C NRM, mass spectra and elementary analysis. The calcium antagonistic activity of these compounds was tested in vitro on rat ileum precontracted with 4 x 10(-3) M barium chloride.

MeSH terms

  • Animals
  • Barium Compounds / antagonists & inhibitors
  • Barium Compounds / pharmacology
  • Calcium Channel Blockers / chemical synthesis*
  • Calcium Channel Blockers / pharmacology
  • Chlorides / antagonists & inhibitors
  • Chlorides / pharmacology
  • Ileum / drug effects
  • In Vitro Techniques
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Muscle Relaxation / drug effects
  • Pyrimidinones / chemical synthesis*
  • Pyrimidinones / pharmacology
  • Rats
  • Spectrophotometry, Infrared
  • Spectrophotometry, Ultraviolet

Substances

  • Barium Compounds
  • Calcium Channel Blockers
  • Chlorides
  • Pyrimidinones
  • barium chloride