Withdrawal of Rotavirus Vaccine Recommendation

MMWR Morb Mortal Wkly Rep. 1999 Nov 5;48(43):1007.

Abstract

In July 1999, CDC recommended that health-care providers and parents postpone use of the rhesus rotavirus vaccine-tetravalent (RRV-TV) (RotaShield, Wyeth Laboratories, Inc., Marietta, Pennsylvania), for infants, at least until November 1999. This action was based on reports to the Vaccine Adverse Event Reporting System of intussusception (a type of bowel obstruction that occurs when the bowel folds in on itself) among 15 infants who received rotavirus vaccine. Also at that time, the manufacturer, in consultation with the Food and Drug Administration, voluntarily ceased further distribution of the vaccine.

MeSH terms

  • Diarrhea, Infantile / prevention & control*
  • Humans
  • Infant
  • Intussusception / chemically induced*
  • Rotavirus / immunology*
  • Rotavirus Vaccines*
  • United States
  • Vaccination / standards*
  • Vaccines, Attenuated / administration & dosage
  • Vaccines, Attenuated / adverse effects*
  • Viral Vaccines / administration & dosage
  • Viral Vaccines / adverse effects*

Substances

  • Rotavirus Vaccines
  • Vaccines, Attenuated
  • Viral Vaccines
  • rhesus rotavirus vaccine