Oral Microflora as a Cause of Endocarditis and Other Distant Site Infections

Infect Dis Clin North Am. 1999 Dec;13(4):833-50, vi. doi: 10.1016/s0891-5520(05)70111-2.


Bacteremia originating from the oral cavity is common, but the role of bacteremia in the genesis of infective endocarditis and other distant site infections is unclear. Only a small percentage of oral flora have been associated with distant site infection. Important issues remain unresolved concerning the identification of patients at risk, the relative risk from invasive dental procedures versus naturally occurring bacteremia, and the impact of prophylactic antibiotics on the incidence, nature, magnitude, and duration of bacteremia from the oral cavity. This article addresses the controversies in infection management in patients at risk for distant site infection.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antibiotic Prophylaxis
  • Bacteremia / etiology*
  • Bacteremia / microbiology
  • Bacteremia / prevention & control
  • Dental Prophylaxis / adverse effects*
  • Endocarditis, Bacterial / etiology*
  • Endocarditis, Bacterial / microbiology
  • Endocarditis, Bacterial / prevention & control
  • Gram-Positive Cocci / isolation & purification
  • Humans
  • Mouth Diseases / complications*
  • Mouth Diseases / microbiology
  • Mouth Diseases / prevention & control
  • Risk Factors