Postoperative recurrence of Crohn's disease: pathophysiology and prevention

Inflamm Bowel Dis. 1999 Nov;5(4):295-303. doi: 10.1097/00054725-199911000-00010.


Postoperative recurrence of Crohn's disease is often inevitable. Certain risk factors such as smoking, young age, and a perforating disease behavior have been identified. Patients running an enhanced risk should be treated with mesalamine or, with higher success rates, with azathioprine. An endoscopic evaluation of the neoterminal ileum 6 to 12 months after surgery provides relevant information predicting the further clinical course and can be used as a guide to adjust medical therapy.

Publication types

  • Review

MeSH terms

  • Crohn Disease / physiopathology
  • Crohn Disease / prevention & control*
  • Crohn Disease / surgery*
  • Female
  • Humans
  • Incidence
  • Male
  • Prognosis
  • Risk Factors
  • Secondary Prevention