Langerhans' cell histiocytosis: paediatric head and neck study

J Otolaryngol. 1999 Oct;28(5):266-72.


Objective: This study presents the experience of the Montreal Children's Hospital (MCH) with Langerhans' cell histiocytosis (LCH) and reviews the new advances in diagnosis and therapy of this disorder.

Design: Retrospective study of 20 patients seen between July 1986 and July 1997 diagnosed with LCH.

Methods: All of the 20 charts were examined for variables including age, sex, area involved, treatment modalities, and complications.

Result: Sixty-five percent of patients presented with localized lesions and 35% with multisystem involvement. The most common involved area was the skull, and 57% of skull lesions involved frontal bone. The temporal bone was involved in 25% of cases. The most common ear symptom was otorrhea.

Conclusion: Langerhans' cell histiocytosis is a rare paediatric disorder. Head and neck involvement occurs frequently in both localized and multisystem disease. The prognosis is highly dependent on the age and number of systems involved.

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Female
  • Follow-Up Studies
  • Head
  • Histiocytosis, Langerhans-Cell / classification
  • Histiocytosis, Langerhans-Cell / complications
  • Histiocytosis, Langerhans-Cell / diagnosis*
  • Histiocytosis, Langerhans-Cell / therapy*
  • Humans
  • Infant
  • Male
  • Neck
  • Retrospective Studies