The IGF-I receptor in cancer research

Exp Cell Res. 1999 Nov 25;253(1):1-6. doi: 10.1006/excr.1999.4667.


The type 1 insulin-like growth factor receptor (IGF-IR) plays an important role in both normal and abnormal growth. It is particularly important in anchorage-independent growth. Impairment of its function causes apoptosis of tumor cells and inhibition of tumor growth in experimental animals. However, the IGF-IR can also induce differentiation, and eventually cell death, of certain types of cells. Its major substrates, IRS-1 and Shc, determine whether the IGF-IR will transform cells or will cause their differentiation.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Transformation, Neoplastic*
  • Genes, Tumor Suppressor
  • Humans
  • Male
  • Mice
  • Neoplasms, Experimental
  • Oncogenes
  • Prostatic Neoplasms / etiology
  • Receptor, IGF Type 1 / metabolism*
  • Research / trends*


  • Receptor, IGF Type 1