Signaling via vascular endothelial growth factor receptors

Exp Cell Res. 1999 Nov 25;253(1):117-30. doi: 10.1006/excr.1999.4707.


Angiogenesis, or development of blood vessels from preexisting vasculature, has important functions under both normal and pathophysiological conditions. Vascular endothelial growth factor receptors 1-3, also known as flt-1, KDR, and flt-4, are endothelial cell-specific receptor tyrosine kinases which serve as key mediators of the angiogenic responses. The review focuses on the signaling pathways that are initiated from these receptors and the recently identified VEGF coreceptor neuroplilin-1.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Endothelium, Vascular / physiology*
  • Gene Expression Regulation
  • Neovascularization, Pathologic*
  • Neovascularization, Physiologic*
  • Nerve Tissue Proteins / metabolism*
  • Neuropilin-1
  • Receptor Protein-Tyrosine Kinases / metabolism*
  • Receptors, Growth Factor / metabolism*
  • Receptors, Vascular Endothelial Growth Factor
  • Signal Transduction


  • Nerve Tissue Proteins
  • Receptors, Growth Factor
  • Neuropilin-1
  • Receptor Protein-Tyrosine Kinases
  • Receptors, Vascular Endothelial Growth Factor