AP-1: one switch for many signals

Exp Cell Res. 1999 Nov 25;253(1):180-5. doi: 10.1006/excr.1999.4685.


The transcription factor AP-1 is activated in response to an incredible array of stimuli, including mitogenic growth factors, inflammatory cytokines, growth factors of the TGF-beta family, UV and ionizing irradiation, cellular stress, antigen binding, and neoplastic transformation. In this review, I discuss genetic evidence that supports a role for AP-1 in the cellular response to some of these stimuli and describe biochemical properties that might explain the ability of this transcription factor to activate different sets of genes in response to different stimuli.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Mitogen-Activated Protein Kinases / metabolism
  • Multigene Family
  • Proto-Oncogene Proteins / metabolism
  • Proto-Oncogene Proteins c-ets
  • Signal Transduction*
  • Transcription Factor AP-1 / genetics
  • Transcription Factor AP-1 / metabolism*
  • Transcription Factors / metabolism


  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-ets
  • Transcription Factor AP-1
  • Transcription Factors
  • Mitogen-Activated Protein Kinases