Bioactive lysophospholipids and their G protein-coupled receptors

Exp Cell Res. 1999 Nov 25;253(1):230-8. doi: 10.1006/excr.1999.4702.


Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are serum-borne lysophospholipids that signal through their cognate G protein-coupled receptors to evoke a great variety of responses in numerous cell types. In addition to stimulating cell proliferation and survival, LPA and S1P induce profound cytoskeletal changes through Rho-mediated signaling pathways, leading to such diverse responses as cell rounding, neurite retraction, and modulation of tumor cell invasiveness (transcellular migration). A major recent advance is the identification of a subfamily of heptahelical receptors for LPA and S1P.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Division / physiology
  • Cytoskeleton / physiology
  • Female
  • GTP-Binding Proteins / metabolism*
  • Humans
  • Lysophospholipids / metabolism*
  • Receptors, Cell Surface / metabolism*
  • Receptors, G-Protein-Coupled*
  • Receptors, Lysophosphatidic Acid
  • Receptors, Lysophospholipid
  • Signal Transduction
  • Sphingosine / analogs & derivatives*
  • Sphingosine / metabolism


  • Lysophospholipids
  • Receptors, Cell Surface
  • Receptors, G-Protein-Coupled
  • Receptors, Lysophosphatidic Acid
  • Receptors, Lysophospholipid
  • sphingosine 1-phosphate
  • GTP-Binding Proteins
  • Sphingosine