Signaling by distinct classes of phosphoinositide 3-kinases

Exp Cell Res. 1999 Nov 25;253(1):239-54. doi: 10.1006/excr.1999.4701.


Many signaling pathways converge on and regulate phosphoinositide 3-kinase (PI3K) enzymes whose inositol lipid products are key mediators of intracellular signaling. Different PI3K isoforms generate specific lipids that bind to FYVE and pleckstrin homology (PH) domains in a variety of proteins, affecting their localization, conformation, and activities. Here we review the activation mechanisms of the different types of PI3Ks and their downstream actions, with focus on the PI3Ks that are acutely triggered by extracellular stimulation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Binding Sites
  • Isoenzymes / antagonists & inhibitors
  • Isoenzymes / classification
  • Isoenzymes / metabolism
  • Mice
  • Mice, Knockout
  • Phosphatidylinositol 3-Kinases / classification*
  • Phosphatidylinositol 3-Kinases / genetics
  • Phosphatidylinositol 3-Kinases / metabolism*
  • Phosphoinositide-3 Kinase Inhibitors
  • Protein Structure, Tertiary
  • Protein-Serine-Threonine Kinases / metabolism
  • Signal Transduction*


  • Isoenzymes
  • Phosphoinositide-3 Kinase Inhibitors
  • Protein-Serine-Threonine Kinases