Multiple roles for Src in a PDGF-stimulated cell

Exp Cell Res. 1999 Nov 25;253(1):271-9. doi: 10.1006/excr.1999.4669.

Abstract

The observation that platelet-derived growth factor (PDGF) increases the catalytic activity of Src family members (Src) suggests that they contribute to PDGF-dependent responses. The role of Src in PDGF-dependent cell cycle progression, phosphorylation of proteins, and chemotaxis has been tested by investigators using a variety of cell types and approaches, and it appears that the contribution of Src is highly variable. This idea is perhaps best illustrated by the finding that Src plays radically different roles downstream of the PDGF alpha- and beta-receptor subunits. Hence, Src is a versatile signal relay enzyme, whose contribution to a signaling cascade depends on variables such as the nature of the receptor via which the cell is activated, as well as the cell type itself.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Cell Cycle
  • Chemotaxis
  • Phosphorylation
  • Platelet-Derived Growth Factor / pharmacology*
  • src-Family Kinases / metabolism*

Substances

  • Platelet-Derived Growth Factor
  • src-Family Kinases