Leydig-cell tumors caused by an activating mutation of the gene encoding the luteinizing hormone receptor

N Engl J Med. 1999 Dec 2;341(23):1731-6. doi: 10.1056/NEJM199912023412304.
No abstract available

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Child
  • Cyclic AMP / biosynthesis
  • Humans
  • Inositol Phosphates / biosynthesis
  • Leydig Cell Tumor / complications
  • Leydig Cell Tumor / genetics*
  • Leydig Cell Tumor / pathology
  • Male
  • Mutation
  • Puberty, Precocious / etiology*
  • Receptors, LH / genetics*
  • Receptors, LH / metabolism
  • Testicular Neoplasms / complications
  • Testicular Neoplasms / genetics*
  • Testicular Neoplasms / pathology
  • Testis / pathology

Substances

  • Inositol Phosphates
  • Receptors, LH
  • Cyclic AMP