Long-term treatment of streptozotocin-induced diabetes by continuous insulin minipump in the Syrian hamster

Cell Transplant. Sep-Oct 1999;8(5):561-5. doi: 10.1177/096368979900800511.

Abstract

It is difficult to normalize plasma glucose for a prolonged period of time by s.c. injection in experimental animals. The goal of this study was to determine the feasibility and the dosage of insulin needed to maintain 24-h normoglycemia in streptozotocin-diabetic Syrian hamsters with a s.c.-implanted osmotic minipump. The pumps, which release insulin at a constant rate, were replaced every 14 days with fresh pumps for as long as 52 days. A high insulin dose (1 U/kg/h) was required to normalize plasma glucose and fatty acid concentrations, water and food consumption, urine output, and body weight.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Glucose / metabolism
  • Body Weight
  • Cricetinae
  • Diabetes Mellitus, Experimental / blood
  • Diabetes Mellitus, Experimental / drug therapy*
  • Fatty Acids, Nonesterified / blood
  • Infusion Pumps, Implantable*
  • Insulin Infusion Systems*
  • Male
  • Mesocricetus

Substances

  • Blood Glucose
  • Fatty Acids, Nonesterified