Non-MHC gene regulation of nerve root injury induced spinal cord inflammation and neuron death

J Neuroimmunol. 1999 Nov 1;101(1):87-97. doi: 10.1016/s0165-5728(99)00136-8.


Spinal ventral root avulsion leads to an inflammatory response around lesioned motoneurons and the subsequent degeneration of a large proportion of the neurons. We demonstrate here differences in the regulation of cytokine mRNAs, microglia/macrophage activation, MHC expression and nerve cell survival in the two inbred rat strains DA and ACI. These strains have similar major MHC haplotypes, but differ in their non-MHC background genes. T cells were rare in the lesioned segments and depletion of T cells did not affect the response. Thus, non-MHC gene(s) regulate the inflammation and neuron death after nerve trauma by mechanisms not involving antigen-specific immune responses.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Death
  • Crosses, Genetic
  • Histocompatibility Antigens Class II / analysis
  • Interferon-gamma / physiology
  • Major Histocompatibility Complex*
  • Motor Neurons / pathology*
  • Myelitis / etiology*
  • Neuroglia / physiology
  • Rats
  • Rats, Inbred ACI
  • Species Specificity
  • Spinal Nerve Roots / injuries*
  • Tumor Necrosis Factor-alpha / physiology


  • Histocompatibility Antigens Class II
  • Tumor Necrosis Factor-alpha
  • Interferon-gamma