Clinical applications of angiogenic growth factors and their inhibitors

Nat Med. 1999 Dec;5(12):1359-64. doi: 10.1038/70928.

Abstract

Promoting the formation of new collateral vessels in ischemic tissues using angiogenic growth factors (therapeutic angiogenesis) is a an exciting frontier of cardiovascular medicine. Conversely, inhibition of the action of key regulators of angiogenesis, such as VEGF, constitutes a promising approach for the treatment of solid tumors and intraocular neovascular syndromes. These concepts are being tested now in clinical trials.

Publication types

  • Review

MeSH terms

  • Animals
  • Coronary Disease / drug therapy
  • Endothelial Growth Factors / antagonists & inhibitors*
  • Endothelial Growth Factors / genetics
  • Endothelial Growth Factors / therapeutic use*
  • Growth Inhibitors / therapeutic use*
  • Humans
  • Ischemia / drug therapy
  • Lymphokines / antagonists & inhibitors*
  • Lymphokines / genetics
  • Lymphokines / therapeutic use*
  • Mice
  • Mice, Knockout
  • Neoplasms, Experimental / blood supply
  • Neoplasms, Experimental / drug therapy
  • Neovascularization, Pathologic / drug therapy
  • Neovascularization, Pathologic / prevention & control
  • Neovascularization, Physiologic / drug effects*
  • Recombinant Proteins / therapeutic use
  • Retinal Vein / drug effects
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors

Substances

  • Endothelial Growth Factors
  • Growth Inhibitors
  • Lymphokines
  • Recombinant Proteins
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors