Distribution of beta-lactamases in actinomycetes

Antimicrob Agents Chemother. 1999 Dec;43(12):3014-7. doi: 10.1128/AAC.43.12.3014.


The distribution of beta-lactamase activities in a collection of actinomycete strains was surveyed. Six of 127 strains were found to produce beta-lactamase. This low frequency was in contrast to the case with Streptomyces species. The producing strains were not related phylogenetically. MICs of benzylpenicillin did not correlate with beta-lactamase production.

MeSH terms

  • Actinomycetales / drug effects
  • Actinomycetales / enzymology*
  • Microbial Sensitivity Tests
  • Penicillin G / pharmacology
  • Penicillin Resistance
  • Penicillins / pharmacology
  • Phylogeny
  • Time Factors
  • beta-Lactamases / metabolism*


  • Penicillins
  • beta-Lactamases
  • Penicillin G