Effects of Indomethacin and Ibuprofen on Mesenteric and Renal Blood Flow in Preterm Infants With Patent Ductus Arteriosus

J Pediatr. 1999 Dec;135(6):733-8. doi: 10.1016/s0022-3476(99)70093-4.


Objective: To evaluate the effect of intravenous ibuprofen and indomethacin for treatment of patent ductus arteriosus (PDA) on mesenteric and renal blood flow velocity in preterm infants.

Study design: Seventeen mechanically ventilated preterm infants (<33 weeks' gestation) with PDA received either 0.2 mg/kg indomethacin (n = 8) or 10 mg/kg ibuprofen (n = 9), infused over 15 minutes. Mesenteric and renal blood flow velocity were measured by using Doppler ultrasonography.

Results: Indomethacin caused a significant reduction in mesenteric and renal blood flow velocity 30 minutes after drug administration; mesenteric and renal blood flow velocity did not return to the pretreatment values by 120 minutes. Ibuprofen did not alter blood flow 30 minutes after treatment, and blood flow increased 120 minutes after treatment. Mesenteric and renal blood flow velocity changes were significantly different between the 2 treatment groups.

Conclusions: Compared with indomethacin, ibuprofen did not significantly reduce mesenteric and renal blood flow velocity.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Ductus Arteriosus, Patent / physiopathology*
  • Humans
  • Ibuprofen / therapeutic use*
  • Infant, Newborn
  • Infant, Premature*
  • Infant, Premature, Diseases / physiopathology*
  • Kidney / blood supply*
  • Mesentery / blood supply*
  • Regional Blood Flow / drug effects


  • Anti-Inflammatory Agents, Non-Steroidal
  • Ibuprofen